Steven C. DeFina

Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)

Kenneth D. Rice, Naing Aay, Neel K. Anand et al. · ACS Medicinal Chemistry Letters · 2012 · 168 citations · Full text

Medicine, Oncology, Pharmacology +14

Recognition of Planar and Nonplanar Ligands in the Malachite Green–RNA Aptamer Complex

Jeremy Flinders, Steven C. DeFina, David M. Brackett et al. · ChemBioChem · 2003 · 97 citations

Life Sciences, Biology, Molecular Biology +17

Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90

Joerg Bussenius, Charles M. Blazey, Naing Aay et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 78 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9

Binding to an RNA Aptamer Changes the Charge Distribution and Conformation of Malachite Green

Dat Nguyen, Steven C. DeFina, William H. Fink et al. · Journal of the American Chemical Society · 2002 · 55 citations

Natural Sciences, Biophysics, Molecular Biology +17

Pyrazolopyrimidines as dual Akt/p70S6K inhibitors

Kenneth D. Rice, Moon H. Kim, Joerg Bussenius et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 28 citations · Full text

Medicine, Oncology, Pharmacology +8