Laurie P. Volak

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

Jude Canon, Karen Rex, Anne Y. Saiki et al. · Nature · 2019 · 2.2K citations

Cancer Immunosurveillance, Clinical Kras, Immunology +5

Discovery of a Covalent Inhibitor of KRAS^G12C (AMG 510) for the Treatment of Solid Tumors

Brian A. Lanman, Jennifer R. Allen, John G. Allen et al. · Journal of Medicinal Chemistry · 2019 · 677 citations · Full text

Drug Target, Solid Tumors, Molecular Biology +20

Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor

Laurie P. Volak, Senait Ghirmai, John R. Cashman et al. · Drug Metabolism and Disposition · 2008 · 192 citations · Full text

Systematic Study of the Glutathione (GSH) Reactivity of<i>N</i>-Arylacrylamides: 1. Effects of Aryl Substitution

Victor J. Cee, Laurie P. Volak, Yuping Chen et al. · Journal of Medicinal Chemistry · 2015 · 149 citations

Discovery of <i>N</i>-(1-Acryloylazetidin-3-yl)-2-(1<i>H</i>-indol-1-yl)acetamides as Covalent Inhibitors of KRAS^G12C

Youngsook Shin, Joon Won Jeong, Ryan P. Wurz et al. · ACS Medicinal Chemistry Letters · 2019 · 101 citations · Full text