Dorothy Levorse

(2<i>S</i>,3<i>S</i>)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-<i>N,N</i>-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-<i>a</i>]- pyridin-6-ylphenyl)butanamide:  A Selective α-Amino Amide Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Scott D. Edmondson, Anthony Mastracchio, Robert J. Mathvink et al. · Journal of Medicinal Chemistry · 2006 · 121 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Difluoroethylamines as an amide isostere in inhibitors of cathepsin K

Élise Isabel, Christophe Mellon, Michael J. Boyd et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 111 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +12

Discovery of Vibegron: A Potent and Selective β₃Adrenergic Receptor Agonist for the Treatment of Overactive Bladder

Scott D. Edmondson, Cheng Zhu, Nam Fung Kar et al. · Journal of Medicinal Chemistry · 2015 · 102 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Ionization Behavior of Amino Lipids for siRNA Delivery: Determination of Ionization Constants, SAR, and the Impact of Lipid p<i>K</i>_a on Cationic Lipid−Biomembrane Interactions

Jingtao Zhang, Haihong Fan, Dorothy Levorse et al. · Langmuir · 2011 · 88 citations

Pharmacy, Biochemistry, Molecular Pharmaceutics +17

Inhibition of Stromelysin-1 (MMP-3) by P₁‘-Biphenylylethyl Carboxyalkyl Dipeptides

Craig K. Esser, Robert L. Bugianesi, Charles G. Caldwell et al. · Journal of Medicinal Chemistry · 1997 · 66 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10