Understanding the Conformational Impact of Chemical Modifications on Monoclonal Antibodies with Diverse Sequence Variation Using Hydrogen/Deuterium Exchange Mass Spectrometry and Structural Modeling

Aming Zhang, Ping Hu, Paul A. MacGregor, +5

Analytical Chemistry

Ionization Behavior of Amino Lipids for siRNA Delivery: Determination of Ionization Constants, SAR, and the Impact of Lipid p<i>K</i>_a on Cationic Lipid−Biomembrane Interactions

Jingtao Zhang, Haihong Fan, Dorothy Levorse, +1

Langmuir

Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape

René Bartz, Haihong Fan, Jingtao Zhang, +11

Biochemical Journal

Peptide/sirna MixturesNanotherapeuticsMolecular BiologyPeptide ScienceGene Delivery +19

Solution Behavior of IFN-β-1a: An Empirical Phase Diagram Based Approach

Haihong Fan, John P. Ralston, Mary Dibiase, +2

Journal of Pharmaceutical Sciences

Chemical KineticsEngineeringPhysicsPhase EquilibriumApplied Physics +6

Effects of pH and Polyanions on the Thermal Stability of Fibroblast Growth Factor 20

Haihong Fan, Samadhi N. Vitharana, Tracy Chen, +2

Molecular Pharmaceutics

Tissue EngineeringEngineeringProtein AssemblyProtein Phase SeparationCell Growth +15

Experimental Investigation into the Effect of Pyrolysis on Chemical Forms of Heavy Metals in Sewage Sludge Biochar (SSB), with Brief Ecological Risk Assessment

Binbin Li, Songxiong Ding, Haihong Fan, +1

Materials

Interaction of Cholesterol-Conjugated Ionizable Amino Lipids with Biomembranes: Lipid Polymorphism, Structure–Activity Relationship, and Implications for siRNA Delivery

Jingtao Zhang, Haihong Fan, Dorothy Levorse, +1

Langmuir

Structure–activity RelationshipNanomedicineProteinlipid InteractionEngineeringLipid Sar +11

Effects of Solutes on Empirical Phase Diagrams of Human Fibroblast Growth Factor 1

Haihong Fan, Huaina Li, Mingyu Zhang, +1

Journal of Pharmaceutical Sciences

MechanobiologyFibrosisDevelopmental BiologyCell DivisionEmpirical Phase Diagrams +8

Synergic coordination and precipitation effects induced by free carboxyl for separation of iron(III) and nickel(II) in zirconium-metal-organic framework

Xudong Zhao, Lei Pei, Haihong Fan, +4

Journal of Solid State Chemistry

Materials ScienceInorganic ChemistryEngineeringSynergic CoordinationFree Carboxyl +6

Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates

Stephanie E. Barrett, Rob S. Burke, Marc Abrams, +34

Journal of Controlled Release

Cell-based Drug DeliveryNanomedicineEngineeringPolymer-drug ConjugateNano-drug Delivery +5