Marie-Claude Trachy-Bourget

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity <i>in vitro</i> and <i>in vivo</i>

Marielle Fournel, Claire Bonfils, Yu Hou et al. · Molecular Cancer Therapeutics · 2008 · 333 citations · Full text

Tumor Biology, Inhibitory Activity, Medicine +13

Novel Aminophenyl Benzamide-Type Histone Deacetylase Inhibitors with Enhanced Potency and Selectivity

Oscar Moradei, Tammy C. Mallais, Sylvie Fréchette et al. · Journal of Medicinal Chemistry · 2007 · 161 citations · Full text

Inhibitory Activity, Medicinal Chemistry, Bioorganic Chemistry +15

Discovery of <i>N</i>-(2-Aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an Orally Active Histone Deacetylase Inhibitor

Nancy Zhou, Oscar Moradei, Stéphane Raeppel et al. · Journal of Medicinal Chemistry · 2008 · 108 citations · Full text

Compound 8, Chemoprevention Strategy, Pharmacotherapy +18

Sulfonamide anilides, a novel class of histone deacetylase inhibitors, are antiproliferative against human tumors.

Marielle Fournel, Marie-Claude Trachy-Bourget, Ann Kalita et al. · PubMed · 2002 · 84 citations

Histone Deacetylases, Chemoprevention Strategy, Pharmacotherapy +21

Development of Potential Antitumor Agents. Synthesis and Biological Evaluation of a New Set of Sulfonamide Derivatives as Histone Deacetylase Inhibitors

Giliane Bouchain, Silvana Leit, Sylvie Fréchette et al. · Journal of Medicinal Chemistry · 2003 · 71 citations · Full text

Pharmacotherapy, Hdac Activity, Pharmaceutical Chemistry +18