Concepedia

Silvana Leit

SL

Statistics

Publications

23

Citations

1.3K

H-Index

18

Active since

1999

Affiliations

Pyrogenesis (Canada)(Current)

The Ohio State University

Schrodinger (United States)

Silvana Leit is an author at Pyrogenesis (Canada) specializing in medicinal chemistry, enzyme inhibition, and pharmacology.

Publications per year

1999–2023

23

Publications

23

An allosteric mechanism for potent inhibition of human ATP-citrate lyase

Wei Jia, Silvana Leit, Jun Kuai et al. · Nature · 2019 · 192 citations

, , +13

Novel Aminophenyl Benzamide-Type Histone Deacetylase Inhibitors with Enhanced Potency and Selectivity

Oscar Moradei, Tammy C. Mallais, Sylvie Fréchette et al. · Journal of Medicinal Chemistry · 2007 · 164 citations · Full text

, , +16

Discovery of <i>N</i>-(2-Aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an Orally Active Histone Deacetylase Inhibitor

Nancy Zhou, Oscar Moradei, Stéphane Raeppel et al. · Journal of Medicinal Chemistry · 2008 · 108 citations · Full text

, , +13

Sulfonamide anilides, a novel class of histone deacetylase inhibitors, are antiproliferative against human tumors.

Marielle Fournel, Marie-Claude Trachy-Bourget, Ann Kalita et al. · PubMed · 2002 · 84 citations

, , +14

Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors

David Smil, Sukhdev Manku, Yves Chantigny et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 82 citations · Full text

, , +9

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