Concepedia

Silvana Leit

SL

Statistics

Publications

22

Citations

1.3K

H-Index

18

Active since

1999

Affiliations

Pyrogenesis (Canada)(Current)

The Ohio State University

Schrodinger (United States)

Silvana Leit is an author at Pyrogenesis (Canada) specializing in pharmacology, medicine, and drug discovery.

Top concepts

PharmacologyMedicineDrug DiscoveryBiochemistryNatural SciencesMedicinal ChemistryDrug DevelopmentPharmacotherapyChemical BiologyOrganic Chemistry

Publications per year

1999–2023

22

Publications

22

An allosteric mechanism for potent inhibition of human ATP-citrate lyase

Wei Jia, Silvana Leit, Jun Kuai et al. · Nature · 2019 · 183 citations

Biosynthesis, Biochemistry, Allosteric Mechanism +3

Novel Aminophenyl Benzamide-Type Histone Deacetylase Inhibitors with Enhanced Potency and Selectivity

Oscar Moradei, Tammy C. Mallais, Sylvie Fréchette et al. · Journal of Medicinal Chemistry · 2007 · 161 citations · Full text

Inhibitory Activity, Medicinal Chemistry, Bioorganic Chemistry +15

Discovery of <i>N</i>-(2-Aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an Orally Active Histone Deacetylase Inhibitor

Nancy Zhou, Oscar Moradei, Stéphane Raeppel et al. · Journal of Medicinal Chemistry · 2008 · 108 citations · Full text

Compound 8, Chemoprevention Strategy, Pharmacotherapy +18

Sulfonamide anilides, a novel class of histone deacetylase inhibitors, are antiproliferative against human tumors.

Marielle Fournel, Marie-Claude Trachy-Bourget, Ann Kalita et al. · PubMed · 2002 · 84 citations

Histone Deacetylases, Chemoprevention Strategy, Pharmacotherapy +21

Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors

David Smil, Sukhdev Manku, Yves Chantigny et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 81 citations · Full text

Molecular Pharmacology, Chromatin, Biochemistry +6

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