Role of a p53 polymorphism in the development of human papilloma-virus-associated cancer

Alan Storey, Miranda Thomas, Ann Kalita, +7

Nature

Tumor BiologyP53 PolymorphismOncologyMedicinePathology +7

Two Polymorphic Variants of Wild-Type p53 Differ Biochemically and Biologically

Miranda Thomas, Ann Kalita, Sylvie Labrecque, +3

Molecular and Cellular Biology

GeneticsHuman PolymorphismMolecular BiologyPathologyMolecular Genetics +16

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity <i>in vitro</i> and <i>in vivo</i>

Marielle Fournel, Claire Bonfils, Yu Hou, +17

Molecular Cancer Therapeutics

Tumor BiologyInhibitory ActivityMedicineHdac IsotypePharmacology +11

Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia

Guillermo Garcia‐Manero, Sarit Assouline, Jörge E. Cortes, +16

Blood

Phase I Study of MGCD0103 Given As a Three-Times-Per-Week Oral Dose in Patients With Advanced Solid Tumors

Lillian L. Siu, Ignacio Durán, Wells A. Messersmith, +12

Journal of Clinical Oncology

Discovery of <i>N</i>-(2-Aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an Orally Active Histone Deacetylase Inhibitor

Nancy Zhou, Oscar Moradei, Stéphane Raeppel, +19

Journal of Medicinal Chemistry

Compound 8Chemoprevention StrategyPharmacotherapyInduces HistoneChemical Biology +16

Evaluation of the Pharmacodynamic Effects of MGCD0103 from Preclinical Models to Human Using a Novel HDAC Enzyme Assay

Claire Bonfils, Ann Kalita, Marja Dubay, +6

Clinical Cancer Research

Sulfonamide anilides, a novel class of histone deacetylase inhibitors, are antiproliferative against human tumors.

Marielle Fournel, Marie-Claude Trachy-Bourget, Ann Kalita, +10

PubMed

Histone DeacetylasesChemoprevention StrategyPharmacotherapyCancer BiologyPharmaceutical Chemistry +19

Development of Potential Antitumor Agents. Synthesis and Biological Evaluation of a New Set of Sulfonamide Derivatives as Histone Deacetylase Inhibitors

Giliane Bouchain, Silvana Leit, Sylvie Fréchette, +14

Journal of Medicinal Chemistry

PharmacotherapyHdac ActivityPharmaceutical ChemistryTumor BiologyMedicinal Chemistry +16

Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors

Isabelle Paquin, Stéphane Raeppel, Silvana Leit, +22

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryBioorganic ChemistryBiochemistryNatural Sciences +9