Metformin inhibits the senescence‐associated secretory phenotype by interfering with <scp>IKK</scp>/<scp>NF</scp>‐κ<scp>B</scp> activation

Olga Moiseeva, Xavier Deschênes‐Simard, Emmanuelle St‐Germain, +6

Aging Cell

Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway

Frédéric Lessard, Sebastian Igelmann, Christian Trahan, +17

Nature Cell Biology

ChromatinRb PathwayCycle ArrestCellular SenescenceCell Cycle +3

A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence

Mariana Acevedo, Mathieu Vernier, Lian Mignacca, +5

Cancer Research

Cell DeathCell ProliferationCancer BiologyEpigeneticsTumor Biology +16

A hydride transfer complex reprograms NAD metabolism and bypasses senescence

Sebastian Igelmann, Frédéric Lessard, Oro Uchenunu, +26

Molecular Cell

Chemical BiologyRedox SignalingBiochemistryNatural SciencesMolecular Biology +6

Myc Down-regulation as a Mechanism to Activate the Rb Pathway in STAT5A-induced Senescence

Frédérick A. Mallette, Marie‐France Gaumont‐Leclerc, Geneviève Huot, +1

Journal of Biological Chemistry

CHES1/FOXN3 regulates cell proliferation by repressing PIM2 and protein biosynthesis

Geneviève Huot, Mathieu Vernier, Véronique Bourdeau, +5

Molecular Biology of the Cell

Pim2 ExpressionsCell CycleCancer BiologyTumor BiologyTranscriptional Regulation +14

Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at serine 22 during interphase

Olga Moiseeva, Stéphane Lopes‐Paciencia, Geneviève Huot, +2

Aging

Protein SecretionMolecular BiologyFaulty Serine 22CytoskeletonSerine 22 +15

Phosphorylation of SOCS1 Inhibits the SOCS1–p53 Tumor Suppressor Axis

Emmanuelle Saint‐Germain, Lian Mignacca, Geneviève Huot, +8

Cancer Research

Cancer ResearchSocs1 InhibitsSocs1-p53 Senescence PathwaySignal TransductionSocs1-p53 Pathway +12

Molecular tools that block maturation of the nuclear lamin A and decelerate cancer cell migration

Alexios N. Matralis, Dimitrios Xanthopoulos, Geneviève Huot, +5

Bioorganic & Medicinal Chemistry

MedicineNuclear LaminMolecular BiologyCancer Cell BiologyCell-matrix Interaction +6