Geneviève Huot

Metformin inhibits the senescence‐associated secretory phenotype by interfering with <scp>IKK</scp>/<scp>NF</scp>‐κ<scp>B</scp> activation

Olga Moiseeva, Xavier Deschênes‐Simard, Emmanuelle St‐Germain et al. · Aging Cell · 2013 · 605 citations · Full text

Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway

Frédéric Lessard, Sebastian Igelmann, Christian Trahan et al. · Nature Cell Biology · 2018 · 165 citations

Chromatin, Rb Pathway, Cycle Arrest +5

A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence

Mariana Acevedo, Mathieu Vernier, Lian Mignacca et al. · Cancer Research · 2016 · 55 citations · Full text

Cell Death, Cell Proliferation, Cancer Biology +18

A hydride transfer complex reprograms NAD metabolism and bypasses senescence

Sebastian Igelmann, Frédéric Lessard, Oro Uchenunu et al. · Molecular Cell · 2021 · 54 citations

Chemical Biology, Redox Signaling, Biochemistry +8

Myc Down-regulation as a Mechanism to Activate the Rb Pathway in STAT5A-induced Senescence

Frédérick A. Mallette, Marie‐France Gaumont‐Leclerc, Geneviève Huot et al. · Journal of Biological Chemistry · 2007 · 48 citations · Full text