Sebastian Igelmann

Metformin inhibits the senescence‐associated secretory phenotype by interfering with <scp>IKK</scp>/<scp>NF</scp>‐κ<scp>B</scp> activation

Olga Moiseeva, Xavier Deschênes‐Simard, Emmanuelle St‐Germain et al. · Aging Cell · 2013 · 605 citations · Full text

Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation

Xavier Deschênes‐Simard, Marie‐France Gaumont‐Leclerc, Véronique Bourdeau et al. · Genes & Development · 2013 · 188 citations · Full text

Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway

Frédéric Lessard, Sebastian Igelmann, Christian Trahan et al. · Nature Cell Biology · 2018 · 165 citations

Chromatin, Rb Pathway, Cycle Arrest +5

A hydride transfer complex reprograms NAD metabolism and bypasses senescence

Sebastian Igelmann, Frédéric Lessard, Oro Uchenunu et al. · Molecular Cell · 2021 · 54 citations

Chemical Biology, Redox Signaling, Biochemistry +8

Circumventing senescence is associated with stem cell properties and metformin sensitivity

Xavier Deschênes‐Simard, Maxime Parisotto, Marie‐Camille Rowell et al. · Aging Cell · 2019 · 51 citations · Full text