Frédéric Lessard

Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation

Xavier Deschênes‐Simard, Marie‐France Gaumont‐Leclerc, Véronique Bourdeau et al. · Genes & Development · 2013 · 188 citations · Full text

Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway

Frédéric Lessard, Sebastian Igelmann, Christian Trahan et al. · Nature Cell Biology · 2018 · 165 citations

Chromatin, Rb Pathway, Cycle Arrest +5

Loss of Human Ribosomal Gene CpG Methylation Enhances Cryptic RNA Polymerase II Transcription and Disrupts Ribosomal RNA Processing

Thérèse Gagnon-Kugler, Frédèric Langlois, Victor Y. Stefanovsky et al. · Molecular Cell · 2009 · 114 citations · Full text

Chromatin, Natural Sciences, Genetics +10

The ARF Tumor Suppressor Controls Ribosome Biogenesis by Regulating the RNA Polymerase I Transcription Factor TTF-I

Frédéric Lessard, Françoise Morin, Stacey Ivanchuk et al. · Molecular Cell · 2010 · 97 citations · Full text

Natural Sciences, Transcription Regulation, Rna Polymerase +9

Conditional Inactivation of Upstream Binding Factor Reveals Its Epigenetic Functions and the Existence of a Somatic Nucleolar Precursor Body

Nourdine Hamdane, Victor Y. Stefanovsky, Michel G. Tremblay et al. · PLoS Genetics · 2014 · 89 citations · Full text

Ribosomal Rna, Epigenetic Change, Genetics +25