Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation

Xavier Deschênes‐Simard, Marie‐France Gaumont‐Leclerc, Véronique Bourdeau, +10

Genes & Development

Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway

Frédéric Lessard, Sebastian Igelmann, Christian Trahan, +17

Nature Cell Biology

ChromatinRb PathwayCycle ArrestCellular SenescenceCell Cycle +3

Loss of Human Ribosomal Gene CpG Methylation Enhances Cryptic RNA Polymerase II Transcription and Disrupts Ribosomal RNA Processing

Thérèse Gagnon-Kugler, Frédèric Langlois, Victor Y. Stefanovsky, +2

Molecular Cell

ChromatinNatural SciencesGeneticsDna MethylationEpigenetic Change +8

The ARF Tumor Suppressor Controls Ribosome Biogenesis by Regulating the RNA Polymerase I Transcription Factor TTF-I

Frédéric Lessard, Françoise Morin, Stacey Ivanchuk, +4

Molecular Cell

Natural SciencesTranscription RegulationRna PolymeraseMolecular BiologySmall Rna +7

Conditional Inactivation of Upstream Binding Factor Reveals Its Epigenetic Functions and the Existence of a Somatic Nucleolar Precursor Body

Nourdine Hamdane, Victor Y. Stefanovsky, Michel G. Tremblay, +6

PLoS Genetics

Ribosomal RnaEpigenetic ChangeGeneticsEpigenetic FunctionsEpigenetics +23

NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor

Marina Bury, Benjamin Le Calvé, Frédéric Lessard, +5

Cell Reports

Tumor BiologyOncologyMedicineTumor GrowthColon Tumor Growth +10

The chemotherapeutic agent CX-5461 irreversibly blocks RNA polymerase I initiation and promoter release to cause nucleolar disruption, DNA damage and cell inviability

Jean-Clément Mars, Michel G. Tremblay, Mélissa Valere, +4

NAR Cancer

Cellular senescence and protein degradation

Xavier Deschênes‐Simard, Frédéric Lessard, Marie‐France Gaumont‐Leclerc, +2

Cell Cycle

A model for the topology of active ribosomal RNA genes

Serguei Denissov, Frédéric Lessard, Christine Mayer, +5

EMBO Reports

BiologyNatural SciencesRna Structure PredictionComputational BiologyRna Biology +8

A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence

Mariana Acevedo, Mathieu Vernier, Lian Mignacca, +5

Cancer Research

Cell DeathCell ProliferationCancer BiologyEpigeneticsTumor Biology +16