Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway

Frédéric Lessard, Sebastian Igelmann, Christian Trahan, +17

Nature Cell Biology

ChromatinRb PathwayCycle ArrestCellular SenescenceCell Cycle +3

SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes

Emmanuelle Saint‐Germain, Lian Mignacca, Mathieu Vernier, +3

Aging

Molecular BiologyRedox BiologyTumor BiologyOxidative StressP53 Target Genes +14

A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence

Mariana Acevedo, Mathieu Vernier, Lian Mignacca, +5

Cancer Research

Cell DeathCell ProliferationCancer BiologyEpigeneticsTumor Biology +16

A hydride transfer complex reprograms NAD metabolism and bypasses senescence

Sebastian Igelmann, Frédéric Lessard, Oro Uchenunu, +26

Molecular Cell

Chemical BiologyRedox SignalingBiochemistryNatural SciencesMolecular Biology +6

Sponges against miR-19 and miR-155 reactivate the p53-Socs1 axis in hematopoietic cancers

Lian Mignacca, Emmanuelle Saint‐Germain, Alexandre Benoît, +3

Cytokine

P53-socs1 AxisHematopoietic CancersMicrorna DetectionCell BiologySmall Rna +6

Quantitative SUMO proteomics reveals the modulation of several PML nuclear body associated proteins and an anti-senescence function of UBC9

Francis P. McManus, Véronique Bourdeau, Mariana Acevedo, +6

Scientific Reports

Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex

Neylen Del Toro, Ana Fernández Ruiz, Lian Mignacca, +10

Cell Cycle

Molecular RegulationMolecular BiologyCell CycleRibosomal Protein Rpl22/el22Cancer Biology +18

Phosphorylation of SOCS1 Inhibits the SOCS1–p53 Tumor Suppressor Axis

Emmanuelle Saint‐Germain, Lian Mignacca, Geneviève Huot, +8

Cancer Research

Cancer ResearchSocs1 InhibitsSocs1-p53 Senescence PathwaySignal TransductionSocs1-p53 Pathway +12

SOCS1: phosphorylation, dimerization and tumor suppression

Frédéric Lessard, Emmanuelle Saint‐Germain, Lian Mignacca, +1

Oncoscience

Signal TransductionSignaling PathwayFamily MembersSocs ProteinsReceptor Tyrosine Kinase +11

Targeting ribosome biogenesis reinforces ERK-dependent senescence in pancreatic cancer

MC. Rowell, Xavier Deschênes‐Simard, Stéphane Lopes‐Paciencia, +15

Cell Cycle

OncologyPancreatic CancerMedicineSenescence BiomarkersSenescence Response +11