Rodney A. Bednar

Discovery of the Dual Orexin Receptor Antagonist [(7<i>R</i>)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2<i>H</i>-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

Christopher D. Cox, Michael J. Breslin, David B. Whitman et al. · Journal of Medicinal Chemistry · 2010 · 367 citations · Full text

Psychotropic Medication, Pharmacotherapy, Primary Insomnia +17

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents

P.H. Hutson, Eleftheria N. Finger, Brian C. Magliaro et al. · Neuropharmacology · 2011 · 139 citations

Synaptic Plasticity, Medicine, Synaptic Transmission +9

Discovery of [(2<i>R</i>,5<i>R</i>)‐5‐{[(5‐Fluoropyridin‐2‐yl)oxy]methyl}‐2‐methylpiperidin‐1‐yl][5‐methyl‐2‐(pyrimidin‐2‐yl)phenyl]methanone (MK‐6096): A Dual Orexin Receptor Antagonist with Potent Sleep‐Promoting Properties

Paul J. Coleman, John D. Schreier, Christopher D. Cox et al. · ChemMedChem · 2012 · 121 citations

Sleep Disorders, Neurotransmitter, Peptide Science +19

Reactivity and pH dependence of thiol conjugation to N-ethylmaleimide: detection of a conformational change in chalcone isomerase

Rodney A. Bednar · Biochemistry · 1990 · 120 citations

Purification and characterization of chalcone isomerase from soybeans.

Rodney A. Bednar, John R. Hadcock · Journal of Biological Chemistry · 1988 · 108 citations · Full text

Food Chemistry, Biosynthesis, Engineering +15