Ai Takano

Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

Mami Matano, Shoichi Date, Mariko Shimokawa et al. · Nature Medicine · 2015 · 1.1K citations

Life Sciences, Biotechnology, Molecular Biology +16

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

Masayuki Fujii, Mariko Shimokawa, Shoichi Date et al. · Cell stem cell · 2016 · 853 citations · Full text

Medicine, Cancer Biology, Oncology +12

Visualization and targeting of LGR5+ human colon cancer stem cells

Mariko Shimokawa, Yuki Ohta, Shingo Nishikori et al. · Nature · 2017 · 749 citations

Medicine, Cell Biology, Oncology +10

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

Masayuki Fujii, Mami Matano, Kohta Toshimitsu et al. · Cell stem cell · 2018 · 564 citations · Full text

Life Sciences, Biology, Cell Biology +14

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

Kosaku Nanki, Kohta Toshimitsu, Ai Takano et al. · Cell · 2018 · 343 citations · Full text

Medicine, Cancer Biology, Oncology +16