Shoichi Date

Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

Mami Matano, Shoichi Date, Mariko Shimokawa et al. · Nature Medicine · 2015 · 1.1K citations

Colorectal Cancer, Genome Engineering, Gene Editing +6

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

Masayuki Fujii, Mariko Shimokawa, Shoichi Date et al. · Cell stem cell · 2016 · 823 citations · Full text

Tumor Biology, Oncology, Tumor Heterogeneity +9

Visualization and targeting of LGR5+ human colon cancer stem cells

Mariko Shimokawa, Yuki Ohta, Shingo Nishikori et al. · Nature · 2017 · 728 citations

Tumor Biology, Biological Microenvironments, Cancer Genomics +6

Somatic inflammatory gene mutations in human ulcerative colitis epithelium

Kosaku Nanki, Masayuki Fujii, Mariko Shimokawa et al. · Nature · 2019 · 315 citations

Inflammation, Autoimmune Disease, Pathogenesis +4

Reconstruction of the Human Colon Epithelium In Vivo

Shinya Sugimoto, Yuki Ohta, Masayuki Fujii et al. · Cell stem cell · 2017 · 192 citations · Full text

Human Colon Epithelium, Histopathology, Gastroenterology +4