Shinya Sugimoto

Visualization and targeting of LGR5+ human colon cancer stem cells

Mariko Shimokawa, Yuki Ohta, Shingo Nishikori et al. · Nature · 2017 · 728 citations

Tumor Biology, Biological Microenvironments, Cancer Genomics +6

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

Takashi Seino, Shintaro Kawasaki, Mariko Shimokawa et al. · Cell stem cell · 2018 · 614 citations

Tumor Biology, Lineage Plasticity, Pancreatic Cancer +9

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

Masayuki Fujii, Mami Matano, Kohta Toshimitsu et al. · Cell stem cell · 2018 · 537 citations · Full text

Biology, Gut-organ Axis, Morphogenesis +8

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

Kosaku Nanki, Kohta Toshimitsu, Ai Takano et al. · Cell · 2018 · 333 citations · Full text

Human Gastric Carcinogenesis, Gastrointestinal Oncology, Oncogenic Agent +8

Somatic inflammatory gene mutations in human ulcerative colitis epithelium

Kosaku Nanki, Masayuki Fujii, Mariko Shimokawa et al. · Nature · 2019 · 315 citations

Inflammation, Autoimmune Disease, Pathogenesis +4