Kohta Toshimitsu

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

Masayuki Fujii, Mariko Shimokawa, Shoichi Date et al. · Cell stem cell · 2016 · 823 citations · Full text

Tumor Biology, Oncology, Tumor Heterogeneity +9

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

Takashi Seino, Shintaro Kawasaki, Mariko Shimokawa et al. · Cell stem cell · 2018 · 614 citations

Tumor Biology, Lineage Plasticity, Pancreatic Cancer +9

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

Masayuki Fujii, Mami Matano, Kohta Toshimitsu et al. · Cell stem cell · 2018 · 537 citations · Full text

Biology, Gut-organ Axis, Morphogenesis +8

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

Kosaku Nanki, Kohta Toshimitsu, Ai Takano et al. · Cell · 2018 · 333 citations · Full text

Human Gastric Carcinogenesis, Gastrointestinal Oncology, Oncogenic Agent +8

Somatic inflammatory gene mutations in human ulcerative colitis epithelium

Kosaku Nanki, Masayuki Fujii, Mariko Shimokawa et al. · Nature · 2019 · 315 citations

Inflammation, Autoimmune Disease, Pathogenesis +4