A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

Masayuki Fujii, Mariko Shimokawa, Shoichi Date, +11

Cell stem cell

Tumor BiologyOncologyTumor HeterogeneityNiche Factor RequirementsMedicine +7

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

Takashi Seino, Shintaro Kawasaki, Mariko Shimokawa, +16

Cell stem cell

Tumor BiologyLineage PlasticityPancreatic CancerDisease ProgressionMedicine +7

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

Masayuki Fujii, Mami Matano, Kohta Toshimitsu, +5

Cell stem cell

BiologyGut-organ AxisMorphogenesisNiche-inspired Culture ConditionDigestive Tract +6

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

Kosaku Nanki, Kohta Toshimitsu, Ai Takano, +20

Cell

Human Gastric CarcinogenesisGastrointestinal OncologyOncogenic AgentMedicineDivergent Routes +6

Somatic inflammatory gene mutations in human ulcerative colitis epithelium

Kosaku Nanki, Masayuki Fujii, Mariko Shimokawa, +18

Nature

InflammationAutoimmune DiseasePathogenesisGastroenterologyPathology +2

An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping

Kenta Kawasaki, Kohta Toshimitsu, Mami Matano, +33

Cell

Neuro-oncologyDevelopmental BiologyNeuroendocrine DisorderCerebral OrganoidNeuroendocrine Tumors +3

An organoid-based organ-repurposing approach to treat short bowel syndrome

Shinya Sugimoto, Eiji Kobayashi, Masayuki Fujii, +11

Nature

Regenerative MedicineIntestinal TransplantationShort Bowel SyndromeGastrointestinal PharmacologyGastroenterology +4

Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer

Kohta Toshimitsu, Ai Takano, Masayuki Fujii, +5

Nature Chemical Biology

ChromatinColorectal CancerPathologyCancer GenomicsHuman Colorectal Cancer +3

Silencing of <i>microRNA‐122</i> is an early event during hepatocarcinogenesis from non‐alcoholic steatohepatitis

Yoko Takaki, Yoshimasa Saito, Azusa Takasugi, +10

Cancer Science

ImmunologyPathologyFatty Liver DiseaseNon‐alcoholic SteatohepatitisNon-alcoholic Steatohepatitis +19

Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma

Kenta Kawasaki, Masayuki Fujii, Shinya Sugimoto, +9

Gastroenterology

Developmental BiologyTraditional Serrated AdenomaGenetic EngineeringPathologyHuman Colon-derived Organoids +3