Melissa Pink

PI3Kγ is a molecular switch that controls immune suppression

Megan M. Kaneda, Karen Messer, Natacha Ralainirina et al. · Nature · 2016 · 1.2K citations

Life Sciences, Immunology, Molecular Biology +14

Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

Olivier De Henau, Matthew Rausch, David A. Winkler et al. · Nature · 2016 · 865 citations

Medicine, Cancer Biology, Oncology +14

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

Jonathan D. Finn, Amy Smith, Mihir Patel et al. · Cell Reports · 2018 · 847 citations · Full text

Life Sciences, Biotechnology, Molecular Genetics +17

PI3K-δ and PI3K-γ Inhibition by IPI-145 Abrogates Immune Responses and Suppresses Activity in Autoimmune and Inflammatory Disease Models

David G. Winkler, Jonathan P. DiNitto, Janid A. Ali et al. · Chemistry & Biology · 2013 · 258 citations

Life Sciences, Immunology, Pathology +15

Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)

Martin Tremblay, André Lescarbeau, Michael J. Grogan et al. · Journal of Medicinal Chemistry · 2009 · 251 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17