Jan Tebbe

Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β

Simon J. Henderson, Christin Andersson, Rajesh Narwal et al. · Brain · 2013 · 75 citations · Full text

Peripheral Amyloid-β, Alzheimer's Disease, Degenerative Pathology +17

Engineering Neprilysin Activity and Specificity to Create a Novel Therapeutic for Alzheimer’s Disease

Carl I. Webster, Matthew Burrell, Lise‐Lotte Olsson et al. · PLoS ONE · 2014 · 71 citations · Full text

Crystal structure of the purine nucleoside phosphorylase (PNP) from Cellulomonas sp. and its implication for the mechanism of trimeric PNPs

Jan Tebbe, Agnieszka Bzowska, Beata Wielgus‐Kutrowska et al. · Journal of Molecular Biology · 1999 · 64 citations

Crystal Structure, Biochemistry, Enzyme Catalysis +6

Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases

Moritz J. Schmidt, Ashish Gupta, Christien Bednarski et al. · Nature Communications · 2021 · 55 citations · Full text

Engineering, Molecular Biology, Gene Delivery +19

Preclinical Antitumor Efficacy of BAY 1129980—a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody–Drug Conjugate for the Treatment of Non–Small Cell Lung Cancer

Jörg Willuda, Lars Lindén, Hans‐Georg Lerchen et al. · Molecular Cancer Therapeutics · 2017 · 45 citations