Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study

Scott Antonia, Sarah B. Goldberg, Ani Sarkis Balmanoukian, +8

The Lancet Oncology

Phase 1BMedicineImmunologyPharmacologyImmune Checkpoint Inhibitor +5

A computational multiscale agent-based model for simulating spatio-temporal tumour immune response to PD1 and PDL1 inhibition

Chang Gong, Oleg Milberg, Bing Wang, +4

Journal of The Royal Society Interface

Population Pharmacokinetics of Durvalumab in Cancer Patients and Association With Longitudinal Biomarkers of Disease Status

Paul Baverel, Vincent F. S. Dubois, Chao Yu Jin, +10

Clinical Pharmacology & Therapeutics

Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo

Darren J. Schofield, Lorraine Irving, Laura Calò, +23

Neurobiology of Disease

A QSP Model for Predicting Clinical Responses to Monotherapy, Combination and Sequential Therapy Following CTLA-4, PD-1, and PD-L1 Checkpoint Blockade

Oleg Milberg, Chang Gong, Mohammad Jafarnejad, +6

Scientific Reports

Clinical Activity, Tolerability, and Long-Term Follow-Up of Durvalumab in Patients With Advanced NSCLC

Scott Antonia, Ani Sarkis Balmanoukian, Julie R. Brahmer, +28

Journal of Thoracic Oncology

Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β

Simon J. Henderson, Christin Andersson, Rajesh Narwal, +12

Brain

Peripheral Amyloid-βAlzheimer's DiseaseDegenerative PathologyProtein MisfoldingNeurology +15

MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

Yoshimi Endo Greer, Samuel F. Gilbert, Brunilde Gril, +5

Breast Cancer Research

A Computational Model of Neoadjuvant PD-1 Inhibition in Non-Small Cell Lung Cancer

Mohammad Jafarnejad, Chang Gong, Edward Gabrielson, +6

The AAPS Journal

<i>In silico</i> simulation of a clinical trial with anti-CTLA-4 and anti-PD-L1 immunotherapies in metastatic breast cancer using a systems pharmacology model

Hanwen Wang, Oleg Milberg, Imke H. Bartelink, +6

Royal Society Open Science

Breast OncologyImmunologyPharmacotherapyImmunotherapeuticsImmune Checkpoint Blockade +20