Bruce J. Fahr

Allosteric inhibition of protein tyrosine phosphatase 1B

Christian Wiesmann, Kenneth J. Barr, Jenny Kung et al. · Nature Structural & Molecular Biology · 2004 · 530 citations

Life Sciences, Biochemistry, Molecular Biology +14

Identification of Potent and Selective Small-Molecule Inhibitors of Caspase-3 through the Use of Extended Tethering and Structure-Based Drug Design

Ingrid Choong, Willard Lew, Dennis Lee et al. · Journal of Medicinal Chemistry · 2002 · 105 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Fragment-Based Discovery of Nonpeptidic BACE-1 Inhibitors Using Tethering

Wenjin Yang, Raymond V. Fucini, Bruce J. Fahr et al. · Biochemistry · 2009 · 49 citations

Life Sciences, Biochemistry, Medicinal Chemistry +17

Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator

Anna M. Puzio‐Kuter, Lizhong Xu, Mary Kate McBrayer et al. · Cancer Discovery · 2025 · 48 citations · Full text

Medicine, Oncology, Pharmacology +15

Discovery of Rezatapopt (PC14586), a First-in-Class, Small-Molecule Reactivator of p53 Y220C Mutant in Development

Binh Thanh Vu, Romyr Dominique, Bruce J. Fahr et al. · ACS Medicinal Chemistry Letters · 2024 · 38 citations · Full text

Medicine, Molecular Biology, Oncology +13