De-Ming Chau

An APP inhibitory domain containing the Flemish mutation residue modulates γ-secretase activity for Aβ production

Yuan Tian, Bhramdeo Bassit, De-Ming Chau et al. · Nature Structural & Molecular Biology · 2010 · 90 citations

Protein Secretion, Protein Function, Signal Transduction +8

Modulation of γ-secretase specificity using small molecule allosteric inhibitors

Christopher C. Shelton, Lei Zhu, De-Ming Chau et al. · Proceedings of the National Academy of Sciences · 2009 · 81 citations · Full text

Molecular Pharmacology, γ-Secretase Specificity, Protein Function +15

Piperidine Acetic Acid Based γ-Secretase Modulators Directly Bind to Presenilin-1

Christina J. Crump, Benjamin A. Fish, Suita V. Castro et al. · ACS Chemical Neuroscience · 2011 · 62 citations · Full text

Protein Secretion, Molecular Biology, Amyloid Precursor Protein +16

Familial Alzheimer Disease Presenilin-1 Mutations Alter the Active Site Conformation of γ-secretase

De-Ming Chau, Christina J. Crump, Jennifer C. Villa et al. · Journal of Biological Chemistry · 2012 · 62 citations · Full text

Ps1 Fad Mutations, Molecular Biology, Neurochemical Biomarkers +21

Antibacterial and antifungal activity of kenaf seed peptides and their effect on microbiological safety and physicochemical properties of some food models

Brisha Arulrajah, Mohammed S. Qoms, Belal J. Muhialdin et al. · Food Control · 2022 · 31 citations

Food Chemistry, Antifungal Agent, Food Bioactive Compound +11