Christina J. Crump

The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease

Ji‐Yeun Hur, Georgia Frost, Xianzhong Wu et al. · Nature · 2020 · 360 citations · Full text

Neurodegenerative Diseases, Alzheimer's Disease, Medicine +8

γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin

Nikolay Pozdnyakov, Heather E. Murrey, Christina J. Crump et al. · Journal of Biological Chemistry · 2013 · 103 citations · Full text

Protein Secretion, Molecular Biology, Neurochemical Biomarkers +20

BMS-708,163 Targets Presenilin and Lacks Notch-Sparing Activity

Christina J. Crump, Suita V. Castro, Feng Wang et al. · Biochemistry · 2012 · 93 citations · Full text

Molecular Pharmacology, Signal Transduction, Alzheimer's Disease +15

Piperidine Acetic Acid Based γ-Secretase Modulators Directly Bind to Presenilin-1

Christina J. Crump, Benjamin A. Fish, Suita V. Castro et al. · ACS Chemical Neuroscience · 2011 · 62 citations · Full text

Protein Secretion, Molecular Biology, Amyloid Precursor Protein +16

Familial Alzheimer Disease Presenilin-1 Mutations Alter the Active Site Conformation of γ-secretase

De-Ming Chau, Christina J. Crump, Jennifer C. Villa et al. · Journal of Biological Chemistry · 2012 · 62 citations · Full text

Ps1 Fad Mutations, Molecular Biology, Neurochemical Biomarkers +21