Development of α-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease

Youngchool Choe, Linda S. Brinen, Mark S. Price, +12

Bioorganic & Medicinal Chemistry

BiochemistryMedicineNatural SciencesChaperonesCysteine Protease +6

Novel Benzo[1,4]diazepin-2-one Derivatives as Endothelin Receptor Antagonists

Martin H. Bolli, Judith Marfurt, Corinna Grisostomi, +12

Journal of Medicinal Chemistry

A Strategically Positioned Cation Is Crucial for Efficient Catalysis by Chorismate Mutase

Peter Kast, Corinna Grisostomi, Irene A. Chen, +4

Journal of Biological Chemistry

Achiral, Cheap, and Potent Inhibitors of Plasmepsins I, II, and IV

Christoph Boss, Olivier Corminboeuf, Corinna Grisostomi, +7

ChemMedChem

Bioorganic ChemistryAntiparasitic AgentImmunologyGlycobiologyPharmacotherapy +21

Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors

Olivier Bezençon, Daniel Bur, Thomas Weller, +14

Journal of Medicinal Chemistry

Medicinal ChemistryDrug TargetPharmaceutical ScienceBiochemistryRenin Inhibitors +12

Efficientin VivoSynthesis and Rapid Purification of Chorismic Acid Using an EngineeredEscherichia coliStrain

Corinna Grisostomi, Peter Kast, Rosalino Pulido, +2

Bioorganic Chemistry

Engineeredescherichia ColistrainBiomanufacturingBiosynthesisEngineeringBiochemistry +10

Discovery and Characterization of ACT‐451840: an Antimalarial Drug with a Novel Mechanism of Action

Christoph Boss, Hamed Aissaoui, Nathalie Amaral, +30

ChemMedChem

Drug TargetAntiparasitic AgentAntimalarial DrugMalariaMolecular Biology +14

Preparation, Antiepileptic Activity, and Cardiovascular Safety of Dihydropyrazoles as Brain-Penetrant T-Type Calcium Channel Blockers

Luboš Remeň, Olivier Bezençon, Lloyd J. Simons, +10

Journal of Medicinal Chemistry

Medicinal ChemistryNeurophysiologyMedicineAntiepileptic ActivityCompound 6C +12

Piperidine-based renin inhibitors: Upper chain optimization

Olivier Corminboeuf, Olivier Bezençon, L’uboš Remeň, +9

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineRational Drug DesignMechanism Of ActionUpper Chain Optimization +5

New classes of potent and bioavailable human renin inhibitors

L’uboš Remeň, Olivier Bezençon, Sylvia Richard‐Bildstein, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineRational Drug DesignPharmacotherapyNew Classes +4