Achiral, Cheap, and Potent Inhibitors of Plasmepsins I, II, and IV

Abstract

A novel class of molecules targeting aspartic proteinases from P. falciparum is described. Synthesis of these easily available, achiral, and highly potent molecules was supported by structural information and eventually allowed the identification of compounds highly active against three vacuolar aspartic proteinases. In a red blood cell assay, the growth of P. falciparum (strain K1) could be effectively prevented. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2452/2006/z600223_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.