Alan L. Leggett

The dTAG system for immediate and target-specific protein degradation

Behnam Nabet, Justin M. Roberts, Dennis L. Buckley et al. · Nature Chemical Biology · 2018 · 1.1K citations · Full text

Protein Function, Protein Expression, Protein Folding +6

Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

Behnam Nabet, Fleur M. Ferguson, Bo Kyung A. Seong et al. · Nature Communications · 2020 · 293 citations · Full text

CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

Hua Zhang, Camilla L. Christensen, Ruben Dries et al. · Cancer Cell · 2019 · 215 citations · Full text

Cancer Immunosurveillance, Medicine, Immunology +7

EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

Amanda Balboni Iniguez, Björn Stolte, Emily Jue Wang et al. · Cancer Cell · 2018 · 167 citations · Full text

Tumor Biology, Ewing Sarcoma, Medicine +8

Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype

Yanke Liang, Alan L. Leggett, Woojun D. Park et al. · Cell chemical biology · 2019 · 161 citations · Full text

Signal Transduction, Signaling Pathway, Cell Division +8