The dTAG system for immediate and target-specific protein degradation

Behnam Nabet, Justin M. Roberts, Dennis L. Buckley, +15

Nature Chemical Biology

Protein FunctionProtein ExpressionProtein FoldingNatural SciencesMolecular Biology +4

Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

Behnam Nabet, Fleur M. Ferguson, Bo Kyung A. Seong, +10

Nature Communications

CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

Hua Zhang, Camilla L. Christensen, Ruben Dries, +45

Cancer Cell

Cancer ImmunosurveillanceMedicineImmunologyTumor ImmunityImmune Checkpoint Inhibitor +5

EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

Amanda Balboni Iniguez, Björn Stolte, Emily Jue Wang, +14

Cancer Cell

Tumor BiologyEwing SarcomaMedicineCancer Cell BiologyCdk12 Inhibition +6

Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype

Yanke Liang, Alan L. Leggett, Woojun D. Park, +14

Cell chemical biology

Signal TransductionSignaling PathwayCell DivisionMolecular PathwayCell Regulation +6

Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13

Mei Zeng, Nicholas Kwiatkowski, Tinghu Zhang, +19

eLife

Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression

Maria Rusan, Kapsok Li, Yvonne Li, +30

Cancer Discovery

SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform

John M. Hatcher, Guowei Wu, Chuyue Zeng, +13

Cell chemical biology

Anti-angiogenic IsoformAngiogenesisCovalent Srpk1/2 InhibitorMedicinePotently Converts Vegf +8

Discovery of a selective inhibitor of doublecortin like kinase 1

Fleur M. Ferguson, Behnam Nabet, Srivatsan Raghavan, +34

Nature Chemical Biology

MedicineReceptor Tyrosine KinaseKinase 1PharmacologyCell Biology +3

Inflammasome Modulation by Chemotherapeutics in Malignant Mesothelioma

Catherine M. Westbom, Joyce K. Thompson, Alan L. Leggett, +5

PLoS ONE

ImmunologyPathologyCell DeathCancer BiologyTumor Biology +16