Concepedia

Author

Arnaud Tiberghien

Spirogen (United Kingdom)ORCID

Also Known As

A. Tiberghien, Arnaud C. Tiberghien, Arnaud Tiberghien, Tiberghien, A, Tiberghien, Arnaud

83

Publications

1.6K

Citations

19

H-Index

35

Concepts

All Affiliations

Spirogen (United Kingdom)Cancer Research UKUniversity College LondonUniversity of LondonAstraZeneca (United Kingdom)
AT

About

Arnaud Tiberghien is an author at Spirogen (United Kingdom) specializing in medicine, drug discovery, and medicinal chemistry.

Top Concepts

#ConceptH-IndexPublicationsCitations

1

Medicine

12

13

672

2

Natural Sciences

9

9

582

3

Biomolecular Engineering

7

7

461

4

Biochemistry

3

3

174

5

Engineering

2

2

25

Arnaud Tiberghien

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25

Publications

1.5K

Citations

19

H-Index

YearCitations

A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology

Scott C. Jeffrey, Patrick Burke, Robert P. Lyon,

Bioconjugate Chemistry

2013

241

ADCT-402, a PBD dimer–containing antibody drug conjugate targeting CD19-expressing malignancies

Francesca Zammarchi, Simon Corbett, Lauren Adams,

Blood

2018

174

Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload

Arnaud Tiberghien, Jean-Noel Levy, Luke A. Masterson,

ACS Medicinal Chemistry Letters

2016

161

Genetically Encoded Azide Containing Amino Acid in Mammalian Cells Enables Site-Specific Antibody–Drug Conjugates Using Click Cycloaddition Chemistry

Michael Pete VanBrunt, Kurt Shanebeck, Zachary Caldwell,

Bioconjugate Chemistry

2015

137

ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer–Containing Antibody–Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies

Michael Flynn, Francesca Zammarchi, Peter Tyrer,

Molecular Cancer Therapeutics

2016

125

Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine

John A. Hartley, Michael Flynn, John P. Bingham,

Scientific Reports

2018

123

SLC46A3 as a Potential Predictive Biomarker for Antibody–Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads

Krista Kinneer, John Meekin, Arnaud Tiberghien,

Clinical Cancer Research

2018

81

Design, Synthesis, and Biophysical and Biological Evaluation of a Series of Pyrrolobenzodiazepine−Poly(<i>N</i>-methylpyrrole) Conjugates

Geoffrey Wells, Christopher R. Martin, Philip W. Howard,

Journal of Medicinal Chemistry

2006

79

SG2285, a Novel C2-Aryl-Substituted Pyrrolobenzodiazepine Dimer Prodrug That Cross-links DNA and Exerts Highly Potent Antitumor Activity

John A. Hartley, Anzu Hamaguchi, Marissa Coffils,

Cancer Research

2010

59

Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates

Mary Jane Hinrichs, Pauline M. Ryan, Bo Zheng,

Clinical Cancer Research

2017

43

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