Luke A. Masterson

A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology

Scott C. Jeffrey, Patrick Burke, Robert P. Lyon et al. · Bioconjugate Chemistry · 2013 · 241 citations

Drug Target, Immunology, Molecular Biology +21

Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload

Arnaud Tiberghien, Jean-Noel Levy, Luke A. Masterson et al. · ACS Medicinal Chemistry Letters · 2016 · 161 citations · Full text

Genetically Encoded Azide Containing Amino Acid in Mammalian Cells Enables Site-Specific Antibody–Drug Conjugates Using Click Cycloaddition Chemistry

Michael Pete VanBrunt, Kurt Shanebeck, Zachary Caldwell et al. · Bioconjugate Chemistry · 2015 · 137 citations

Medicinal Chemistry, Drug Targeting, Biochemistry +15

ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer–Containing Antibody–Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies

Michael Flynn, Francesca Zammarchi, Peter Tyrer et al. · Molecular Cancer Therapeutics · 2016 · 125 citations · Full text

Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine

John A. Hartley, Michael Flynn, John P. Bingham et al. · Scientific Reports · 2018 · 123 citations · Full text