Darren Dressen

Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model

Anh P. Truong, G. Toth, Gary D. Probst et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 48 citations · Full text

Pharmacological Study, Biochemistry, Medicine +9

Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors

Anh P. Truong, Danielle L. Aubele, Gary D. Probst et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 36 citations · Full text

Structure–activity Relationship, Medicinal Chemistry, Pharmaceutical Science +11

Preparation and Optimization of a Series of 3-Carboxamido-5-phenacylaminopyrazole Bradykinin B1 Receptor Antagonists

Darren Dressen, Albert W. Garofalo, Jon E. Hawkinson et al. · Journal of Medicinal Chemistry · 2007 · 35 citations · Full text

Pharmaceutical Science, Pain Medicine, N-substituted Pyrazoles +17

Discovery of (<i>R</i>)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND006) and (<i>R</i>)-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch

Gary D. Probst, Danielle L. Aubele, Simeon Bowers et al. · Journal of Medicinal Chemistry · 2013 · 32 citations

Molecular Pharmacology, Medicinal Chemistry, Synthetic Strategy +14

Design and synthesis of cell potent BACE-1 inhibitors: Structure–activity relationship of P1′ substituents

Jennifer M. Sealy, Anh P. Truong, Luke S. Tso et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 31 citations · Full text

Structure–activity Relationship, Molecular Pharmacology, Medicinal Chemistry +13