Jon E. Hawkinson

Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.

Richard B. Carter, Paul L. Wood, Scott Wieland et al. · PubMed · 1997 · 251 citations

Gamma-aminobutyric Acid, Pharmacotherapy, Experimental Pharmacology +16

Characterization of the Anticonvulsant Properties of Ganaxolone (CCD 1042; 3α-Hydroxy-3β-methyl-5α-pregnan-20-one), a Selective, High-Affinity, Steroid Modulator of the γ-Aminobutyric AcidA Receptor

Richard B. Carter, Paul L. Wood, Scott Wieland et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 131 citations

Medicinal Chemistry, Medicine, Hormonal Receptor +7

Subtype-Selective <i>N</i>-Methyl-<scp>d</scp>-aspartate Receptor Antagonists:  Synthesis and Biological Evaluation of 1-(Arylalkynyl)-4-benzylpiperidines

Jon L. Wright, Tracy F. Gregory, Christopher F. Bigge et al. · Journal of Medicinal Chemistry · 1999 · 95 citations · Full text

Correlation of neuroactive steroid modulation of [35S]t-butylbicyclophosphorothionate and [3H]flunitrazepam binding and gamma-aminobutyric acidA receptor function.

Jon E. Hawkinson, Catherine L. Kimbrough, Delia Belelli et al. · Molecular Pharmacology · 1994 · 91 citations

Synthesis and <i>in Vitro</i> Activity of 3β-Substituted-3α-hydroxypregnan-20-ones:  Allosteric Modulators of the GABA_A Receptor

Derk J. Hogenkamp, S. Hasan Tahir, Jon E. Hawkinson et al. · Journal of Medicinal Chemistry · 1997 · 69 citations · Full text