Daisuke Tomita

Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

Lodoe Lama, Carolina Adura, Wei Xie et al. · Nature Communications · 2019 · 283 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Enantioselective Synthesis of SM-130686 Based on the Development of Asymmetric Cu(I)F Catalysis To Access 2-Oxindoles Containing a Tetrasubstituted Carbon

Daisuke Tomita, Kenzo Yamatsugu, Motomu Kanai et al. · Journal of the American Chemical Society · 2009 · 280 citations

Natural Sciences, Chemistry, Medicinal Chemistry +13

Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation

Wei Xie, Lodoe Lama, Carolina Adura et al. · Proceedings of the National Academy of Sciences · 2019 · 205 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response

Akito Nakamura, Tadahiro Nambu, Shunsuke Ebara et al. · Proceedings of the National Academy of Sciences · 2018 · 170 citations · Full text

Medicine, Oncology, Pharmacology +16

Enantioselective Alkenylation and Phenylation Catalyzed by a Chiral CuF Complex

Daisuke Tomita, Reiko Wada, Motomu Kanai et al. · Journal of the American Chemical Society · 2005 · 155 citations

Natural Sciences, Chemistry, Catalysis +7