Denise C. Grünenfelder

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan et al. · Nature · 2016 · 893 citations

Cancer Research, Allosteric Inhibition, Signal Transduction +12

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

Jorge Fortanet, Christine Hiu-Tung Chen, Ying-Nan P. Chen et al. · Journal of Medicinal Chemistry · 2016 · 284 citations · Full text

Allosteric Inhibition, Drug Target, Shp2 Inhibition +20

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer

Matthew J. LaMarche, Michael Acker, Andreea Argintaru et al. · Journal of Medicinal Chemistry · 2020 · 207 citations · Full text

Radical Deoxychlorination of Cesium Oxalates for the Synthesis of Alkyl Chlorides

Justin Y. Su, Denise C. Grünenfelder, Kohei Takeuchi et al. · Organic Letters · 2018 · 49 citations

Radical Deoxychlorination, Chemical Engineering, Novel Organocatalysts +11

Enantioselective Synthesis of (−)‐10‐Hydroxyacutuminine

Denise C. Grünenfelder, Raul Navarro, Haoxuan Wang et al. · Angewandte Chemie International Edition · 2022 · 19 citations · Full text

Unexpected Cyclopropane-containing Pentacycle, Heterocyclic, Acutumine Scaffold +8