Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells

Matthew B. Dong, Guangchuan Wang, Ryan D. Chow, +17

Cell

Off-target EffectGenome SurgeryCd8 T CellsImmunologyVivo Crispr Screens +9

In vivo CRISPR screening in CD8 T cells with AAV–Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma

Lupeng Ye, Jonathan J. Park, Matthew B. Dong, +9

Nature Biotechnology

GliomaCd8 T CellsImmunologyTumor ImmunityVivo Crispr Screening +8

A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy

Lupeng Ye, Jonathan J. Park, Lei Peng, +17

Cell Metabolism

Car-t TherapyImmunologyGenetic EngineeringGenome EngineeringGenome Editing +6

One-step generation of modular CAR-T cells with AAV–Cpf1

Xiaoyun Dai, Jonathan J. Park, Yaying Du, +4

Nature Methods

MedicineImmunologyT Cell ImmunityCell SystemsCellular Immune Response +5

CRISPR-GEMM Pooled Mutagenic Screening Identifies KMT2D as a Major Modulator of Immune Checkpoint Blockade

Guangchuan Wang, Ryan D. Chow, Lvyun Zhu, +16

Cancer Discovery

Up-regulation of ceRNA TINCR by SP1 contributes to tumorigenesis in breast cancer

Yun Liu, Yaying Du, Lu Zhao, +1

BMC Cancer

Long non-coding RNA BLACAT1 promotes breast cancer cell proliferation and metastasis by miR-150-5p/CCR2

Yun Liu, Yaying Du, Teng Cheng, +1

Cell & Bioscience

Massively parallel knock-in engineering of human T cells

Xiaoyun Dai, Jonathan J. Park, Yaying Du, +12

Nature Biotechnology

Human CellCell TherapyMedicineCell TransplantationBiomedical Engineering +5

CAR-T Cells Targeting TSHR Demonstrate Safety and Potent Preclinical Activity Against Differentiated Thyroid Cancer

Hanning Li, Xiang Zhou, Ge Wang, +13

The Journal of Clinical Endocrinology & Metabolism

SIX1 Activates STAT3 Signaling to Promote the Proliferation of Thyroid Carcinoma via EYA1

Deguang Kong, Anping Li, Yu Liu, +8

Frontiers in Oncology