Yaying Du

Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells

Matthew B. Dong, Guangchuan Wang, Ryan D. Chow et al. · Cell · 2019 · 308 citations · Full text

Off-target Effect, Genome Surgery, Cd8 T Cells +11

In vivo CRISPR screening in CD8 T cells with AAV–Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma

Lupeng Ye, Jonathan J. Park, Matthew B. Dong et al. · Nature Biotechnology · 2019 · 201 citations

Glioma, Cd8 T Cells, Immunology +10

A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy

Lupeng Ye, Jonathan J. Park, Lei Peng et al. · Cell Metabolism · 2022 · 181 citations · Full text

Car-t Therapy, Immunology, Genetic Engineering +8

One-step generation of modular CAR-T cells with AAV–Cpf1

Xiaoyun Dai, Jonathan J. Park, Yaying Du et al. · Nature Methods · 2019 · 162 citations

Medicine, Immunology, T Cell Immunity +7

CRISPR-GEMM Pooled Mutagenic Screening Identifies KMT2D as a Major Modulator of Immune Checkpoint Blockade

Guangchuan Wang, Ryan D. Chow, Lvyun Zhu et al. · Cancer Discovery · 2020 · 133 citations · Full text