Discovery of Brivanib Alaninate ((<i>S</i>)-((<i>R</i>)-1-(4-(4-Fluoro-2-methyl-1<i>H</i>-indol-5-yloxy)-5-methylpyrrolo[2,1-<i>f</i>][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), A Novel Prodrug of Dual Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 Kinase Inhibitor (BMS-540215)

Zhen‐Wei Cai, Yongzheng Zhang, R. M. Borzilleri, +21

Journal of Medicinal Chemistry

Pharmaceutical ScienceOral BioavailabilityL-alanine Prodrug 8PharmacotherapyPharmaceutical Chemistry +18

Discovery of (<i>R</i>)-7-Cyano-2,3,4,5-tetrahydro-1-(1<i>H</i>-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1<i>H</i>-1,4-benzodiazepine (BMS-214662), a Farnesyltransferase Inhibitor with Potent Preclinical Antitumor Activity

John T. Hunt, Charles Z. Ding, Roberta S. Batorsky, +20

Journal of Medicinal Chemistry

Medicinal Chemistry-1,4-Benzodiazepine FarnesyltransferaseBiochemistryChemoprevention StrategyMedicine +13

Discovery and Preclinical Studies of (<i>R</i>)-1-(4-(4-Fluoro-2-methyl-1<i>H</i>-indol-5-yloxy)-5- methylpyrrolo[2,1-<i>f</i>][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an In Vivo Active Potent VEGFR-2 Inhibitor

Rajeev S. Bhide, Zhen‐Wei Cai, Yong‐Zheng Zhang, +25

Journal of Medicinal Chemistry

Discovery of the Pyrrolo[2,1-<i>f</i>][1,2,4]triazine Nucleus as a New Kinase Inhibitor Template

John T. Hunt, Toomas Mitt, R. M. Borzilleri, +11

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryQuinazoline-based Kinase InhibitorsBiochemistryNatural Sciences +12

Development of Highly Potent Inhibitors of Ras Farnesyltransferase Possessing Cellular and<i>in Vivo</i>Activity

Katerina Leftheris, Toni Kline, Gregory D. Vite, +19

Journal of Medicinal Chemistry

Chemoprevention StrategyA1 Side ChainCellular PharmacologyChemical BiologyPharmaceutical Chemistry +15

The Antiangiogenic Activity in Xenograft Models of Brivanib, a Dual Inhibitor of Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 Kinases

Rajeev S. Bhide, Louis J. Lombardo, John T. Hunt, +12

Molecular Cancer Therapeutics

Design, Synthesis, and Evaluation of Orally Active 4-(2,4-Difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1-<i>f</i>][1,2,4]triazines as Dual Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 Inhibitors

R. M. Borzilleri, Xiaoping Zheng, Ligang Qian, +15

Journal of Medicinal Chemistry

Enzyme KineticsMedicinal ChemistryPharmaceutical ScienceBiochemistryMedicine +12

Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors

Kyoung Soon Kim, Songfeng Lu, Lyndon A. M. Cornelius, +24

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacotherapyDrug DevelopmentEg5 Inhibitors +3

Concise and Efficient Synthesis of 4-Fluoro-1<i>H</i>-pyrrolo[2,3-<i>b</i>]pyridine

Carl Thibault, Alexandre L’Heureux, Rajeev S. Bhide, +1

Organic Letters

Discovery and Structure−Activity Relationships of Imidazole-Containing Tetrahydrobenzodiazepine Inhibitors of Farnesyltransferase

Charles Z. Ding, Roberta S. Batorsky, Rajeev S. Bhide, +20

Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryIp Antitumor ActivityBiochemistryMedicine +13