Katerina Leftheris

Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma

Joshua D. Hansen, Matthew Correa, Mark A. Nagy et al. · Journal of Medicinal Chemistry · 2020 · 204 citations · Full text

Hematological Malignancy, Novel Therapy, Medicine +15

Discovery of (<i>R</i>)-7-Cyano-2,3,4,5-tetrahydro-1-(1<i>H</i>-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1<i>H</i>-1,4-benzodiazepine (BMS-214662), a Farnesyltransferase Inhibitor with Potent Preclinical Antitumor Activity

John T. Hunt, Charles Z. Ding, Roberta S. Batorsky et al. · Journal of Medicinal Chemistry · 2000 · 134 citations · Full text

Medicinal Chemistry, -1,4-Benzodiazepine Farnesyltransferase, Biochemistry +15

Development of Highly Potent Inhibitors of Ras Farnesyltransferase Possessing Cellular and<i>in Vivo</i>Activity

Katerina Leftheris, Toni Kline, Gregory D. Vite et al. · Journal of Medicinal Chemistry · 1996 · 88 citations · Full text

Chemoprevention Strategy, A1 Side Chain, Cellular Pharmacology +17

Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF

Martin Decaris, Johanna Schaub, Chun Chen et al. · Respiratory Research · 2021 · 83 citations · Full text

Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-<i>f</i>][1,2,4]triazine p38α Mitogen-Activated Protein Kinase Inhibitors

John Hynes, Alaric J. Dyckman, Shuqun Lin et al. · Journal of Medicinal Chemistry · 2007 · 81 citations · Full text