Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

Jessica Vincent, Carolina Adura, Pu Gao, +15

Nature Communications

Primary MacrophagesInnate Immune SystemImmunologyImmune RegulationImmunologic Mechanism +19

Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

Lodoe Lama, Carolina Adura, Wei Xie, +21

Nature Communications

Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers

Kemal M. Akat, D’Vesharronne Moore-McGriff, Pavel Morozov, +11

Proceedings of the National Academy of Sciences

Human Heart FailureHeart FailureEngineeringGeneticsBiomedical Engineering +19

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs

Aitor Garzia, Seyed Mehdi Jafarnejad, Cindy Meyer, +8

Nature Communications

Human CLP1 Mutations Alter tRNA Biogenesis, Affecting Both Peripheral and Central Nervous System Function

Ender Karaca, Stefan Weitzer, Davut Pehli̇van, +40

Cell

Affecting Both PeripheralKnockout MouseGenome InstabilityMolecular NeuroscienceGenetics +6

Characterizing Expression and Processing of Precursor and Mature Human tRNAs by Hydro-tRNAseq and PAR-CLIP

Tasos Gogakos, Miguel Brown, Aitor Garzia, +3

Cell Reports

Clinical sensitivity and interpretation of PCR and serological COVID‐19 diagnostics for patients presenting to the hospital

Tyler E. Miller, Wilfredo F. Garcia Beltran, Adam Z. Bard, +33

The FASEB Journal

Viral DiagnosticsDiagnosisDiagnosticsCovid-19 EpidemiologyCovid-19 +14

Eukaryote-Specific Insertion Elements Control Human ARGONAUTE Slicer Activity

Kotaro Nakanishi, Manuel Ascano, Tasos Gogakos, +6

Cell Reports

Crystal StructureSystems BiologyCell DivisionGuide RnaNatural Sciences +13

Marked factor V activity elevation in severe <scp>COVID</scp>‐19 is associated with venous thromboembolism

Jonathan A. Stefely, Bianca B. Christensen, Tasos Gogakos, +4

American Journal of Hematology

Factor VCovid-19 EpidemiologyCovid-19ThrombosisVenous Thrombosis +15

Multicolor microRNA FISH effectively differentiates tumor types

Neil Renwick, Pavol Čekan, Paul A. Masry, +21

Journal of Clinical Investigation

Tumor BiologyMedicineMelanomaPathologyCancer Genomics +13