Matthias Negri

Design, Synthesis, Biological Evaluation and Pharmacokinetics of Bis(hydroxyphenyl) substituted Azoles, Thiophenes, Benzenes, and Aza-Benzenes as Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1)

Emmanuel Bey, Sandrine Marchais‐Oberwinkler, Ruth Werth et al. · Journal of Medicinal Chemistry · 2008 · 107 citations · Full text

Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure

Carsten Jagusch, Matthias Negri, Ulrike E. Hille et al. · Bioorganic & Medicinal Chemistry · 2007 · 83 citations · Full text

Molecular Pharmacology, Heterocyclic Modifications, Pharmaceutical Chemistry +12

New Insights into the SAR and Binding Modes of Bis(hydroxyphenyl)thiophenes and -benzenes: Influence of Additional Substituents on 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) Inhibitory Activity and Selectivity

Emmanuel Bey, Sandrine Marchais‐Oberwinkler, Matthias Negri et al. · Journal of Medicinal Chemistry · 2009 · 75 citations · Full text

Novel Aldosterone Synthase Inhibitors with Extended Carbocyclic Skeleton by a Combined Ligand-Based and Structure-Based Drug Design Approach

Simon Lucas, Ralf Heim, Matthias Negri et al. · Journal of Medicinal Chemistry · 2008 · 72 citations · Full text

Novel CYP17 inhibitors: Synthesis, biological evaluation, structure–activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls

Ulrike E. Hille, Qingzhong Hu, Carsten A. Vock et al. · European Journal of Medicinal Chemistry · 2009 · 70 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Science +13