In Vivo Active Aldosterone Synthase Inhibitors with Improved Selectivity: Lead Optimization Providing a Series of Pyridine Substituted 3,4-Dihydro-1<i>H</i>-quinolin-2-one Derivatives

Simon Lucas, Ralf Heim, Christina Ries, +3

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPlasma Aldosterone LevelsBiochemistryMedicine +13

Novel Aldosterone Synthase Inhibitors with Extended Carbocyclic Skeleton by a Combined Ligand-Based and Structure-Based Drug Design Approach

Simon Lucas, Ralf Heim, Matthias Negri, +6

Journal of Medicinal Chemistry

Fine-Tuning the Selectivity of Aldosterone Synthase Inhibitors: Structure−Activity and Structure−Selectivity Insights from Studies of Heteroaryl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-<i>ij</i>]quinolin-4-one Derivatives

Simon Lucas, Matthias Negri, Ralf Heim, +2

Journal of Medicinal Chemistry

Overcoming Undesirable CYP1A2 Inhibition of Pyridylnaphthalene-Type Aldosterone Synthase Inhibitors: Influence of Heteroaryl Derivatization on Potency and Selectivity

Ralf Heim, Simon Lucas, Cornelia M. Grombein, +5

Journal of Medicinal Chemistry

Medicinal ChemistryUndesirable Cyp1a2 InhibitionBiochemistryIsoquinoline Derivative 30Medicine +13

Expedient Construction of the Vibsanin E Core without the Use of Protecting Groups

Ralf Heim, Stefan Wiedemann, Craig M. Williams, +1

Organic Letters

Towards the Total Synthesis of Vibsanin E, 15‐<i>O</i>‐Methylcyclovibsanin B,3‐Hydroxyvibsanin E, Furanovibsanin A, and 3‐<i>O</i>‐Methylfuranovibsanin A

Brett D. Schwartz, David Tilly, Ralf Heim, +3

European Journal of Organic Chemistry

Bioorganic ChemistryEngineeringVibsanin EOrganic ChemistryMedicinal Chemistry +14

1-Phenylsulfinyl-3-(pyridin-3-yl)naphthalen-2-ols: A new class of potent and selective aldosterone synthase inhibitors

Cornelia M. Grombein, Qingzhong Hu, Ralf Heim, +3

European Journal of Medicinal Chemistry

Medicinal ChemistryBioorganic ChemistryAldo-keto ReductaseBiochemistryMedicine +9

Selective aldosterone synthase inhibitors reduce aldosterone formation in vitro and in vivo

Christina Ries, Simon Lucas, Ralf Heim, +2

The Journal of Steroid Biochemistry and Molecular Biology

Molecular PharmacologyAldo-keto ReductaseMedicinePhysiologyEndocrinology +3

Theoretical studies on the interaction of partial agonists with the 5-HT2A receptor

Maria Elena Silva, Ralf Heim, Sigurd Elz, +1

Journal of Computer-Aided Molecular Design

Signal TransductionFunctional SelectivityMedicinePhysiologyMechanism Of Action +9

Nitrogen is a requirement for the photochemical induced 3-azabicyclo[3.3.1]nonane skeletal rearrangement!

Craig M. Williams, Ralf Heim, Paul V. Bernhardt

Tetrahedron

HeterocyclicPhotochemistryReactive Nitrogen SpecieNatural SciencesMechanistic Photochemistry +5