Ralf Heim

In Vivo Active Aldosterone Synthase Inhibitors with Improved Selectivity: Lead Optimization Providing a Series of Pyridine Substituted 3,4-Dihydro-1<i>H</i>-quinolin-2-one Derivatives

Simon Lucas, Ralf Heim, Christina Ries et al. · Journal of Medicinal Chemistry · 2008 · 78 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Plasma Aldosterone Levels +15

Novel Aldosterone Synthase Inhibitors with Extended Carbocyclic Skeleton by a Combined Ligand-Based and Structure-Based Drug Design Approach

Simon Lucas, Ralf Heim, Matthias Negri et al. · Journal of Medicinal Chemistry · 2008 · 72 citations · Full text

Fine-Tuning the Selectivity of Aldosterone Synthase Inhibitors: Structure−Activity and Structure−Selectivity Insights from Studies of Heteroaryl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-<i>ij</i>]quinolin-4-one Derivatives

Simon Lucas, Matthias Negri, Ralf Heim et al. · Journal of Medicinal Chemistry · 2011 · 66 citations · Full text

Overcoming Undesirable CYP1A2 Inhibition of Pyridylnaphthalene-Type Aldosterone Synthase Inhibitors: Influence of Heteroaryl Derivatization on Potency and Selectivity

Ralf Heim, Simon Lucas, Cornelia M. Grombein et al. · Journal of Medicinal Chemistry · 2008 · 49 citations · Full text

Medicinal Chemistry, Undesirable Cyp1a2 Inhibition, Biochemistry +15

Expedient Construction of the Vibsanin E Core without the Use of Protecting Groups

Ralf Heim, Stefan Wiedemann, Craig M. Williams et al. · Organic Letters · 2005 · 47 citations