Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure

Carsten Jagusch, Matthias Negri, Ulrike E. Hille, +11

Bioorganic & Medicinal Chemistry

Molecular PharmacologyHeterocyclic ModificationsPharmaceutical ChemistryBiochemistryCore Structure +10

Isopropylidene Substitution Increases Activity and Selectivity of Biphenylmethylene 4-Pyridine Type CYP17 Inhibitors

Qingzhong Hu, Lina Yin, Carsten Jagusch, +2

Journal of Medicinal Chemistry

Medicinal ChemistryUrologyBiochemistryMedicineNatural Sciences +13

Novel CYP17 inhibitors: Synthesis, biological evaluation, structure–activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls

Ulrike E. Hille, Qingzhong Hu, Carsten A. Vock, +5

European Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPharmaceutical ScienceDrug TargetBiochemistry +11

Selective Dual Inhibitors of CYP19 and CYP11B2: Targeting Cardiovascular Diseases Hiding in the Shadow of Breast Cancer

Qingzhong Hu, Lina Yin, Rolf W. Hartmann

Journal of Medicinal Chemistry

Novel Imidazol-1-ylmethyl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-<i>ij</i>]quinolin-4-ones as Potent and Selective CYP11B1 Inhibitors for the Treatment of Cushing’s Syndrome

Lina Yin, Simon Lucas, Frauke Maurer, +3

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryCushing ’MedicinePromising Therapy +11

Aldosterone Synthase Inhibitors as Promising Treatments for Mineralocorticoid Dependent Cardiovascular and Renal Diseases

Qingzhong Hu, Lina Yin, Rolf W. Hartmann

Journal of Medicinal Chemistry

HypertensionRenal InflammationCardiovascular PharmacologyPromising TreatmentsPharmacotherapy +29

Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17)—Part II: Core rigidification and influence of substituents at the methylene bridge

Qingzhong Hu, Matthias Negri, Kerstin Jahn‐Hoffmann, +6

Bioorganic & Medicinal Chemistry

Methylene ImidazoleMedicinal ChemistryBiochemistryMethylene BridgeBiocatalysis +8

Tetrahydropyrroloquinolinone Type Dual Inhibitors of Aromatase/Aldosterone Synthase as a Novel Strategy for Breast Cancer Patients with Elevated Cardiovascular Risks

Lina Yin, Qingzhong Hu, Rolf W. Hartmann

Journal of Medicinal Chemistry

Breast OncologyBioorganic ChemistryChemoprevention StrategyPharmacotherapyCardiovascular Toxicity +20

Cushing’s Syndrome: Development of Highly Potent and Selective CYP11B1 Inhibitors of the (Pyridylmethyl)pyridine Type

Juliette Emmerich, Qingzhong Hu, Nina Hanke, +1

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPyridine TypePharmacological StudyBiochemistry +11

Novel Pyridyl- or Isoquinolinyl-Substituted Indolines and Indoles as Potent and Selective Aldosterone Synthase Inhibitors

Lina Yin, Qingzhong Hu, Juliette Emmerich, +4

Journal of Medicinal Chemistry

Isoquinolinyl-substituted IndolinesPharmacotherapyAldosterone LevelsPharmaceutical ChemistryMolecular Pharmacology +16