Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure

Carsten Jagusch, Matthias Negri, Ulrike E. Hille, +11

Bioorganic & Medicinal Chemistry

Molecular PharmacologyHeterocyclic ModificationsPharmaceutical ChemistryBiochemistryCore Structure +10

First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases

Ulrike E. Hille, Christina Zimmer, Carsten A. Vock, +1

ACS Medicinal Chemistry Letters

PharmacotherapyGlucocorticoidTranslational PharmacologyCompound 33Medicinal Chemistry +14

Isopropylidene Substitution Increases Activity and Selectivity of Biphenylmethylene 4-Pyridine Type CYP17 Inhibitors

Qingzhong Hu, Lina Yin, Carsten Jagusch, +2

Journal of Medicinal Chemistry

Medicinal ChemistryUrologyBiochemistryMedicineNatural Sciences +13

Novel CYP17 inhibitors: Synthesis, biological evaluation, structure–activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls

Ulrike E. Hille, Qingzhong Hu, Carsten A. Vock, +5

European Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPharmaceutical ScienceDrug TargetBiochemistry +11

Replacement of Imidazolyl by Pyridyl in Biphenylmethylenes Results in Selective CYP17 and Dual CYP17/CYP11B1 Inhibitors for the Treatment of Prostate Cancer

Qingzhong Hu, Carsten Jagusch, Ulrike E. Hille, +2

Journal of Medicinal Chemistry

Selective Cyp17Chemoprevention StrategyBiphenylmethylenes ResultsPharmacotherapyMedicinal Chemistry +14

Optimization of the First Selective Steroid-11β-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases

Ulrike E. Hille, Christina Zimmer, Jörg Haupenthal, +1

ACS Medicinal Chemistry Letters

Combinatorial ChemistryCortisol Dependent DiseasesOrganic ChemistryPharmacotherapyGlucocorticoid +17

Synthesis, biological evaluation and molecular modelling studies of novel ACD- and ABD-ring steroidomimetics as inhibitors of CYP17

Mariano A. E. Pinto‐Bazurco Mendieta, Matthias Negri, Carsten Jagusch, +5

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design +9

Subcutaneous wash-out procedure (SWOP) for the treatment of chemotherapeutic extravasations

Andreas Steiert, Ulrike E. Hille, William F. Burke, +4

Journal of Plastic Reconstructive & Aesthetic Surgery

Surgical OncologyMinimally Invasive ProcedureSurgeryWound HealingDermatology +3

CYP17 Inhibitors. Annulations of Additional Rings in Methylene Imidazole Substituted Biphenyls: Synthesis, Biological Evaluation and Molecular Modelling

Mariano A. E. Pinto‐Bazurco Mendieta, Matthias Negri, Qingzhong Hu, +7

Archiv der Pharmazie

Bioorganic ChemistryOrganic ChemistryPharmacotherapyHeterocycle ChemistryHuman Cyp17 +16

Steroidogenic cytochrome P450 (CYP) enzymes as drug targets: Combining substructures of known CYP inhibitors leads to compounds with different inhibitory profile

Ulrike E. Hille, Qingzhong Hu, Mariano A. E. Pinto‐Bazurco Mendieta, +4

Comptes Rendus Chimie