Ulrike E. Hille

Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure

Carsten Jagusch, Matthias Negri, Ulrike E. Hille et al. · Bioorganic & Medicinal Chemistry · 2007 · 83 citations · Full text

Molecular Pharmacology, Heterocyclic Modifications, Pharmaceutical Chemistry +12

First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases

Ulrike E. Hille, Christina Zimmer, Carsten A. Vock et al. · ACS Medicinal Chemistry Letters · 2010 · 78 citations · Full text

Pharmacotherapy, Glucocorticoid, Translational Pharmacology +16

Isopropylidene Substitution Increases Activity and Selectivity of Biphenylmethylene 4-Pyridine Type CYP17 Inhibitors

Qingzhong Hu, Lina Yin, Carsten Jagusch et al. · Journal of Medicinal Chemistry · 2010 · 73 citations · Full text

Medicinal Chemistry, Urology, Biochemistry +15

Novel CYP17 inhibitors: Synthesis, biological evaluation, structure–activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls

Ulrike E. Hille, Qingzhong Hu, Carsten A. Vock et al. · European Journal of Medicinal Chemistry · 2009 · 70 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Science +13

Replacement of Imidazolyl by Pyridyl in Biphenylmethylenes Results in Selective CYP17 and Dual CYP17/CYP11B1 Inhibitors for the Treatment of Prostate Cancer

Qingzhong Hu, Carsten Jagusch, Ulrike E. Hille et al. · Journal of Medicinal Chemistry · 2010 · 54 citations · Full text

Selective Cyp17, Chemoprevention Strategy, Biphenylmethylenes Results +16