Jonathan Renshaw

Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2

Richard A. Ward, Nicola Colclough, Mairi Challinor et al. · Journal of Medicinal Chemistry · 2015 · 102 citations · Full text

Small Molecule Inhibitors, Covalent Inhibitors, Drug Target +17

Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily

Jonathan D.J. Wrigley, Gérald Gavory, Iain Simpson et al. · ACS Chemical Biology · 2017 · 84 citations · Full text

Aldo-keto Reductase, Immunology, Molecular Biology +19

Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors

Caroline Colley, Bojana Popovic, Sudharsan Sridharan et al. · mAbs · 2017 · 34 citations · Full text

Crystal Structure, Immunology, Immunodominance +17

Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations

Brendon Ladd, Anne Marie Mazzola, Teeru Bihani et al. · Oncotarget · 2016 · 28 citations · Full text

Improved expression and purification of the Helicobacter pylori adhesin BabA through the incorporation of a hexa-lysine tag

Naim Hage, Jonathan Renshaw, G. Sebastiaan Winkler et al. · Protein Expression and Purification · 2014 · 27 citations · Full text

Biosynthesis, Biochemistry, Natural Sciences +12