Saul Jaime‐Figueroa

Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead

Daniel P. Bondeson, Blake E. Smith, George M. Burslem et al. · Cell chemical biology · 2017 · 867 citations · Full text

Protac Design, Selective Degradation, Biomolecular Engineering +1

The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study

George M. Burslem, Blake E. Smith, Ashton C. Lai et al. · Cell chemical biology · 2017 · 643 citations · Full text

Protein Chemistry, Protein Function, Biochemistry +14

Modular PROTAC Design for the Degradation of Oncogenic BCR‐ABL

Ashton C. Lai, Momar Toure, Doris Hellerschmied et al. · Angewandte Chemie International Edition · 2015 · 606 citations · Full text

Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase

Blake E. Smith, Stephen L. Wang, Saul Jaime‐Figueroa et al. · Nature Communications · 2019 · 502 citations · Full text

Targeting the C481S Ibrutinib-Resistance Mutation in Bruton’s Tyrosine Kinase Using PROTAC-Mediated Degradation

Alexandru D. Buhimschi, Haley A. Armstrong, Momar Toure et al. · Biochemistry · 2018 · 361 citations

Tyrosine Kinase, Immunology, Molecular Biology +19