Hirohito Sone

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

Takashi Matsuzaka, Hitoshi Shimano, Naoya Yahagi et al. · Nature Medicine · 2007 · 535 citations

Obesity, Metabolic Syndrome, Biochemistry +10

Polyunsaturated Fatty Acids Suppress Sterol Regulatory Element-binding Protein 1c Promoter Activity by Inhibition of Liver X Receptor (LXR) Binding to LXR Response Elements

Tomohiro Yoshikawa, Hitoshi Shimano, Naoya Yahagi et al. · Journal of Biological Chemistry · 2002 · 417 citations · Full text

Promoter Activity, Pufa Suppression, Fatty Liver Disease +16

SREBPs suppress IRS-2-mediated insulin signalling in the liver

Tomohiro Ide, Hitoshi Shimano, Naoya Yahagi et al. · Nature Cell Biology · 2004 · 315 citations

Metabolic Syndrome, Signal Transduction, Hepatology +8

Dual regulation of mouse Δ5- and Δ6-desaturase gene expression by SREBP-1 and PPARα

Takashi Matsuzaka, Hitoshi Shimano, Naoya Yahagi et al. · Journal of Lipid Research · 2002 · 290 citations · Full text

Pancreatic beta cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice

Hirohito Sone, Y Kagawa · Diabetologia · 2004 · 279 citations · Full text

Obesity, Metabolic Syndrome, Longevity +9