Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles

Boshi Huang, Wen‐Ming Chen, Tong Zhao, +14

Journal of Medicinal Chemistry

Contemporary Medicinal Chemistry Strategies for the Discovery and Development of Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors

Zhao Wang, Srinivasulu Cherukupalli, Minghui Xie, +8

Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryPotent NnrtisMedicineNatural Sciences +13

Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors

Xiangyi Jiang, Gaochan Wu, Waleed A. Zalloum, +11

RSC Advances

In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP

Dongwei Kang, Da Feng, Lanlan Jing, +8

European Journal of Medicinal Chemistry

Antiviral CompoundNatural SciencesHuman RetrovirusAntiviral Drug DevelopmentTolerant Regions +10

Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties

Xiangyi Jiang, Boshi Huang, Fisayo A. Olotu, +8

European Journal of Medicinal Chemistry

Medicinal ChemistryHigh Fsp3 ValuesMedicineNatural SciencesAntiviral Drug Development +9

Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability

Shujing Xu, Lin Sun, Alexej Dick, +16

European Journal of Medicinal Chemistry

Phenylalanine DerivativesHiv-1 Capsid InhibitorsMedicinal ChemistryCombinatorial ChemistryBiochemistry +9

Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors

Xiangyi Jiang, Boshi Huang, Shawn Rumrill, +15

Communications Chemistry

Discovery of Novel Dihydrothiopyrano[4,3-<i>d</i>]pyrimidine Derivatives as Potent HIV-1 NNRTIs with Significantly Reduced hERG Inhibitory Activity and Improved Resistance Profiles

Zhao Wang, Waleed A. Zalloum, Wenbo Wang, +6

Journal of Medicinal Chemistry

Development of Novel Dihydrofuro[3,4-<i>d</i>]pyrimidine Derivatives as HIV-1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C

Dongwei Kang, Yanying Sun, Da Feng, +10

Journal of Medicinal Chemistry

Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors

Xujie Zhang, Lin Sun, Megan E. Meuser, +14

European Journal of Medicinal Chemistry

Combinatorial ChemistryBiochemistryMechanism StudyMedicineDimerized Phenylalanine Derivatives +5