Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity

Shenghua Gao, Katharina Sylvester, Letian Song, +18

Journal of Medicinal Chemistry

Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library

Gaochan Wu, Waleed A. Zalloum, Megan E. Meuser, +9

European Journal of Medicinal Chemistry

Phenylalanine DerivativesCombinatorial ChemistryMedicinal ChemistryBiochemistryNatural Sciences +7

Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors

Xiangyi Jiang, Gaochan Wu, Waleed A. Zalloum, +11

RSC Advances

2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies

Dongwei Kang, Francesc X. Ruiz, Yanying Sun, +11

Journal of Medicinal Chemistry

Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the “NNRTI Adjacent” Binding Site

Zhipeng Huo, Heng Zhang, Dongwei Kang, +12

ACS Medicinal Chemistry Letters

Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery

Dongwei Kang, Zhao Wang, Heng Zhang, +17

ACS Medicinal Chemistry Letters

Discovery of piperidine-substituted thiazolo[5,4-d]pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors

Dongwei Kang, Tong Zhao, Zhao Wang, +15

Communications Chemistry

In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP

Dongwei Kang, Da Feng, Lanlan Jing, +8

European Journal of Medicinal Chemistry

Antiviral CompoundNatural SciencesHuman RetrovirusAntiviral Drug DevelopmentTolerant Regions +10

Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors

Shenghua Gao, Letian Song, Tobias Claff, +18

Journal of Medicinal Chemistry

Design, synthesis, and antiviral evaluation of novel hydrazone‐substituted thiophene[3,2‐<i>d</i>]pyrimidine derivatives as potent human immunodeficiency virus‐1 inhibitors

Zhao Wang, Dongwei Kang, Meng Chen, +12

Chemical Biology & Drug Design