Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Itay Tirosh, Benjamin Izar, Sanjay M. Prakadan, +33

Science

Melanoma TumorsImmunologyBiological MicroenvironmentsTumor BiologyOncology +17

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

Livnat Jerby‐Arnon, Parin Shah, Michael S. Cuoco, +49

Cell

Cancer ImmunosurveillanceMedicineImmunologyImmune Checkpoint InhibitorTumor Suppressor +5

A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors

Michal Slyper, Caroline Porter, Orr Ashenberg, +47

Nature Medicine

Spatially organized multicellular immune hubs in human colorectal cancer

Karin Pelka, Matan Hofree, Jonathan Chen, +69

Cell

Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma

Kevin Bi, Meng Xiao He, Ziad Bakouny, +27

Cancer Cell

ImmunologyImmune Cell TherapyImmunotherapyImmune Checkpoint BlockadeTumor Biology +14

<i>Ex Vivo</i> Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Russell W. Jenkins, Amir Reza Aref, Patrick H. Lizotte, +81

Cancer Discovery

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

Srivatsan Raghavan, Peter Winter, Andrew W. Navia, +44

Cell

A single-cell landscape of high-grade serous ovarian cancer

Benjamin Izar, Itay Tirosh, Elizabeth H. Stover, +31

Nature Medicine

Tumor HeterogeneityMedicineGynecologySingle-cell LandscapeOncology +3

Adaptive resistance of melanoma cells to <scp>RAF</scp> inhibition via reversible induction of a slowly dividing de‐differentiated state

Mohammad Fallahi‐Sichani, Verena Becker, Benjamin Izar, +7

Molecular Systems Biology

Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion

Chris J. Frangieh, Johannes C. Melms, Pratiksha I. Thakore, +18

Nature Genetics

Tumor BiologyImmune EvasionCancer Immune EvasionOncologyCancer Immunosurveillance +9