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Cell

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Spatially organized multicellular immune hubs in human colorectal cancer

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Cell

Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics

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Cell

Genetic AnalysisSingle Cell SequencingMedicineGeneticsMitochondrial Mutations +5

Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps

Bob Chen, Cherie’ R. Scurrah, Eliot T. McKinley, +49

Cell

Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions

Michael R. Filbin, Arnav Mehta, Alexis M. Schneider, +40

Cell Reports Medicine

Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling

Caleb A. Lareau, Leif S. Ludwig, Christoph Muus, +17

Nature Biotechnology

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Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer

Sarah E. Johnstone, Alejandro Reyes, Yifeng Qi, +18

Cell

Tumor BiologyTumor HeterogeneityMedicineColorectal CancerSystems Biology +2

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA

Cherilyn M. Sirois, Tengchuan Jin, Allison L. Miller, +19

The Journal of Experimental Medicine

Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial

Jun Tian, Jonathan Chen, Sherry Chao, +42

Nature Medicine

Targeting TBK1 to overcome resistance to cancer immunotherapy

Yi Sun, Or‐Yam Revach, Seth Anderson, +56

Nature

Tumor BiologyCancer ImmunosurveillanceImmunologyImmune Checkpoint InhibitorImmunotherapy +3