Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

Brian C. Miller, Debattama R. Sen, Rose Al Abosy, +24

Nature Immunology

Mediate Tumor ControlCancer ImmunosurveillanceImmunologyTumor ImmunityImmune Checkpoint Inhibitor +6

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

Robert T. Manguso, Hans W. Pope, Margaret D. Zimmer, +16

Nature

Identifies Ptpn2Vivo CrisprImmunologyGene EditingGenome Editing +6

Normalizing the environment recapitulates adult human immune traits in laboratory mice

Lalit K. Beura, Sara E. Hamilton, Kevin Bi, +13

Nature

ImmunogeneticsLaboratory MiceAutoimmune DiseaseAllergyImmune Cell Development +7

Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade

Jeffrey J. Ishizuka, Robert T. Manguso, Collins Cheruiyot, +24

Nature

Cancer ImmunosurveillanceTumours Overcomes ResistanceMedicineImmunologyImmune Checkpoint Inhibitor +6

Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma

Kevin Bi, Meng Xiao He, Ziad Bakouny, +27

Cancer Cell

ImmunologyImmune Cell TherapyImmunotherapyImmune Checkpoint BlockadeTumor Biology +14

MultispeQ Beta: a tool for large-scale plant phenotyping connected to the open PhotosynQ network

Sebastian Kuhlgert, Greg Austic, Robert Zegarac, +8

Royal Society Open Science

Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response

Tiffany A. Reese, Kevin Bi, Amal Kambal, +9

Cell Host & Microbe

VaccinationHost ResponseVaccine TargetPathogenesisImmunology +7

Transcriptional mediators of treatment resistance in lethal prostate cancer

Meng Xiao He, Michael S. Cuoco, Jett Crowdis, +34

Nature Medicine

Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma

Ziad Bakouny, David A. Braun, Sachet A. Shukla, +50

Nature Communications

Mixed signature of activation and dysfunction allows human decidual CD8 ⁺ T cells to provide both tolerance and immunity

Anita van der Zwan, Kevin Bi, Errol R. Norwitz, +4

Proceedings of the National Academy of Sciences