RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

Yasushi Ito, Dimitry Ofengeim, Ayaz Najafov, +18

Science

ImmunologyCell DeathNeuroinflammationInflammationAutophagy +15

Activation of Necroptosis in Multiple Sclerosis

Dimitry Ofengeim, Yasushi Ito, Ayaz Najafov, +16

Cell Reports

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

Jiefei Geng, Yasushi Ito, Linyu Shi, +11

Nature Communications

ApoptosisImmunologyCell DeathDependent ApoptosisCell Death Mechanisms +15

Necroptosis and Cancer

Ayaz Najafov, Hongbo Chen, Junying Yuan

Trends in cancer

Tumor BiologyMedicineApoptosisPathologyCell Death +5

Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model

Xufeng Cen, Yanying Chen, Xiaoyan Xu, +8

Nature Communications

Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model

Xiaoyan Xu, Yaqin Sun, Xufeng Cen, +12

Protein & Cell

MitophagyCell DeathNeurochemical BiomarkersDisease PathologiesSynaptic Signaling +23

Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis

Palak Amin, Marcus A. Florez, Ayaz Najafov, +9

Proceedings of the National Academy of Sciences

Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

Ayaz Najafov, Eeva Sommer, Jeffrey M. Axten, +2

Biochemical Journal

Specific InhibitorPdk1 TargetCancer BiologyTumor BiologyMolecular Pharmacology +16

TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL

Ayaz Najafov, Adnan K. Mookhtiar, Hoang Son Luu, +6

Molecular Cell

Signal TransductionSignaling PathwayApoptosisMedicineCell Biology +3

Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death

Hongguang Xia, Ayaz Najafov, Jiefei Geng, +18

The Journal of Cell Biology