RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

Yasushi Ito, Dimitry Ofengeim, Ayaz Najafov, +18

Science

ImmunologyCell DeathNeuroinflammationInflammationAutophagy +15

Activation of Necroptosis in Multiple Sclerosis

Dimitry Ofengeim, Yasushi Ito, Ayaz Najafov, +16

Cell Reports

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

Daichao Xu, Taijie Jin, Hong Zhu, +17

Cell

InflammationSignaling PathwayApoptosisImmunologyRipk1-driven Apoptosis +5

RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease

Dimitry Ofengeim, Sonia Mazzitelli, Yasushi Ito, +10

Proceedings of the National Academy of Sciences

Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration

Sean K. Ryan, Matija Zelic, Yingnan Han, +20

Nature Neuroscience

The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

Jan Wenzel, Josephine Lampe, Helge Müller‐Fielitz, +43

Nature Neuroscience

Chaperone-mediated autophagy degrades mutant p53

Helin Vakifahmetoglu-Norberg, Minsu Kim, Hongguang Xia, +8

Genes & Development

CSF1R signaling is a regulator of pathogenesis in progressive MS

Nellwyn Hagan, John L. Kane, Deepak Grover, +16

Cell Death and Disease

Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis

Palak Amin, Marcus A. Florez, Ayaz Najafov, +9

Proceedings of the National Academy of Sciences

RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis

Matija Zelic, Fabrizio Pontarelli, Lisa Woodworth, +15

Cell Reports