Margs S. Brennan

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

András Kotschy, Zoltán Szlávik, James B. Murray et al. · Nature · 2016 · 1K citations

Mcl1 Inhibitor S63845, Systems Biology, Oncology +11

An Inducible Lentiviral Guide RNA Platform Enables the Identification of Tumor-Essential Genes and Tumor-Promoting Mutations In Vivo

Brandon J. Aubrey, Gemma L. Kelly, Andrew J. Kueh et al. · Cell Reports · 2015 · 414 citations · Full text

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Jonathan B. Baell, David J. Leaver, S.J. Hermans et al. · Nature · 2018 · 300 citations · Full text

Cancer Research, Chromatin, Tumour Growth +12

DNA repair processes are critical mediators of p53-dependent tumor suppression

Ana Janic, Liz J. Valente, Matthew J. Wakefield et al. · Nature Medicine · 2018 · 179 citations

Tumor Biology, Genome Instability, Dna Repair Processes +10

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

Margs S. Brennan, Catherine Chang, Lin Tai et al. · Blood · 2018 · 88 citations · Full text